3. Turner A, Veysey M, Keely S, Scarlett CJ, Lucock M, Beckett EL. Intense Sweeteners, Taste Receptors and the Gut Microbiome: A Metabolic Health Perspective. Int J Environ Res Public Health. 2020 Jun 8;17(11):4094. doi: 10.3390/ijerph17114094. PMID: 32521750; PMCID: PMC7312722."7. ConclusionsTaste receptors may represent a link between the use of IS, intestinal dysbiosis, weight gain and metabolic outcomes. While the metabolic effects of IS consumption on T1Rs have been explored in humans [102], the potential activation of bitter receptors and the downstream metabolic effects of that activation have been largely overlooked. Overall, IS may alter risk for metabolic disorders via interactions with taste receptors and intestinal microbiota. If this is the case, certain dietary or microbial interventions may be used for the prevention or treatment of metabolic conditions related to gastrointestinal dysbiosis and IS consumption. However, further studies are needed to confirm this association in humans and define the mechanisms."
